|Keck Seminar: Subversion of the Innate Immune Response by Pestivirus Npro|
Kay Choi, PhD, Assistant Professor, University of Texas Medical Branch at Galveston
|date:||4:00PM US Central (GMT −0500)|
Friday, November 22, 2013
Kay Choi, PhD
Sealy Center for Structural Biology
Department of Biochemistry & Molecular Biology
University of Texas Medical Branch at Galveston
Mammalian cells respond to viral infection by inducing a complex signal transduction cascade that ultimately mediates cellular antiviral defenses. In particular, viral dsRNA triggers activation of interferon regulatory factor-3 (IRF3), which then induces transcription of interferon genes. Viruses, in turn, have evolved mechanisms to counter the host’s innate immune response by inhibiting this interferon response. Pestiviruses use the virally-encoded N-terminal protease Npro to suppress the interferon induction. Npro interacts with IRF3 and induces its ubiquitination and proteasome-mediated degradation. We are investigating the mechanism of how the interaction between Npro and IRF3 leads to proteasomal degradation of IRF3. I will discuss recent structural and functional studies of Npro that illuminate both its autoprotease activity and its ability to inhibit IRF3.
Dr. Chen’s Research:
Our research focuses on the structure and mechanism of viral replication and infection machinery using X-ray crystallography and cryo-electron microscopy. High-resolution X-ray crystal structures of individual component proteins can be fitted into lower resolution cryo-EM density maps to generate pseudo-atomic structure of large macromolecular complexes.
|more info:||Gulf Coast Consortia|
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