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Keck Seminar: Real-time Metabolic and Molecular Imaging by Hyperpolarization
Pratip Bhattacharya, PhD
date:4:00PM   US Central (GMT −0500)
Friday, September 6, 2013
location:BRC Auditorium, BioScience Research Collaborative Building, Rice University
sponsor:Gulf Coast Consortia

Pratip Bhattacharya, PhD
Associate Professor
Cancer Systems Imaging
The University of Texas MD Anderson Cancer Center

Hyperpolarized MR is a non-toxic, non-radioactive method for assessing tissue metabolism and other physiologic properties. Hyperpolarization allows for over 50,000 fold signal enhancement relative to conventional magnetic resonance imaging (MRI) or spectroscopy (MRS). After hyperpolarization, the signal enhancement can be retained on the metabolites of the hyperpolarized molecules for several minutes. Many laboratories are working on techniques to extend this relaxation time so that more detailed metabolic studies can be considered.
My laboratory has worked on three different modalities of hyperpolarization; both on the technique development as well as developing novel in vivo applications. My seminar will focus on the different in vivo applications of Parahydrogen Induced Polarization (PHIP) (13C), continuous flow Dynamic Nuclear Polarization (DNP) of water (1H) and long lived DNP hyperpolarized signal of Silicon nanoparticles (29Si). The overall goal of our program at the University of Texas, M. D. Anderson Cancer Center is to develop the hyperpolarized imaging modality for visualizing metabolism and other molecular events in real time wherein the local status of cancer metabolism in human subjects be interrogated on the time scale of seconds to minutes with unprecedented chemical specificity and MR sensitivity where both early detection as well as the efficacy of cancer therapy can be imaged.

more info:Gulf Coast Consortia
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