|Keck Seminar: Computational Design of Enhanced Learning Protocols|
John H. “Jack” Byrne, PhD, Professor & Chair, Neurobiology & Anatomy, University of Texas Medical School
|date:||4:00PM US Central (GMT −0500)|
Friday, April 5, 2013
|location:||BRC Auditorium, BioScience Research Collaborative Building, Rice University|
|sponsor:||Gulf Coast Consortia|
In the fields of neuroscience and experimental psychology, multiple learning trials spaced over time generally produce long-term memory more effectively than a single trial or multiple trials massed together. However, virtually all of the learning protocols and their neuronal analogues used in animal and human studies have been developed on an ad hoc basis. The optimal procedure or spacing of trials is not predicted by any learning theory. The seminar will demonstrate the feasibility of using computational models of biochemical signaling in nerve cells to design enhanced training protocols that increase synaptic plasticity, transcriptional activation, and long-term memory. Moreover, the seminar will illustrate that a detailed understanding of biochemical signaling pathways underlying synaptic plasticity, as represented in a computational model, can facilitate the development of training protocols that can rescue deficits resulting from a molecular lesion.
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